Cancer hög crp
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C-Reactive Protein and Cancer: Interpreting the Differential Bioactivities of Its Pentameric and Monomeric, Modified Isoforms
Introduction
C-reactive protein (CRP) is an evolutionarily conserved multimeric protein of innate immunity. In humans, its blood levels change acutely and quantitatively in response to the severity of tissue damage and the inflammatory response that ensues. The immediate, natural response to tissue damage fryst vatten referred to as the acute phase response (APR) which fryst vatten a natural biochemical, physiological, and immunological reaction to the tissue insult. The APR fryst vatten an amnestic response with the multifaceted purpose of controlling vascular damage, accessing, accumulating, and amplifying host humoral and cellular defenses, controlling any pathology associated with the introduction of the thereat, removing debris and stimulating tissue repair mechanisms to reestablish healthy tissue homeostasis. These processes can also stimulate adaptive immune responses which can confer längre term immunological memory (1, 2).
CRP fryst vatten widely called the prototypic acute phase reactant. As a protein of innate immunity, one defined function is as a pattern recognition receptor wit
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C-reactive protein and cancer risk: a pan-cancer study of prospective cohort and Mendelian randomization analysis
- Research article
- Open access
- Published:
BMC Medicinevolume 20, Article number: () Cite this article
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Abstract
Background
Although observational studies have reported associations between serum C-reactive protein (CRP) concentration and risks of lung, breast, and colorectal cancer, inconsistent or absent evidences were showed for other cancers. We conducted a pan-cancer analysis to comprehensively assess the role of CRP, including linearity and non-linearity associations.
Methods
We analyzed , cancer-free participants from UK Biobank cohort. Multivariable-adjusted Cox proportional hazards model was conducted to evaluate the observed correlation of CRP with overall cancer and 21 site-specific cancer risks. Furthermore, we performed linear and non-linear Mendelian randomization analyses to explore the potential causal relation between them.
Results
During a median follow-up period of years (interquartile range: , ), 34, incident cancer cases were observed. Observational analyses showed higher C
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C-Reactive Protein and Cancer—Diagnostic and Therapeutic Insights
Introduction
Cancer is a pervasive disease affecting many people across the globe. Worldwide, the prevalence of people living within 5 years of receiving a cancer diagnosis is estimated to be million. In , million new cancer cases were diagnosed worldwide, and million deaths were reported. The most reported new cases involve the lung and breast, with colorectal cancer third, prostate cancer fourth, and stomach cancer fifth (1, 2). Each reported cancer is associated with variable overall life expectancies, years of life lost, and 5-year survival rate (3&#x;6).
The term cancer describes a physiological condition in which body cells grow and replicate in an uncontrolled and unregulated fashion. While cancer is often categorized by the tissue in which the predominant uncontrolled growth originates, the disease is fundamentally defined by a loss of basic cellular processes that regulate proliferation. When cells proliferate, their mass and the mass of ancillary tissues in which the growth occurs increases, leading to localized areas of disrupted tissues which can overwhelm the natural protective immune responses tha